期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 89, 页码 12543-12560出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc06445h
关键词
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资金
- Natural Sciences and Engineering Resource Council (NSERC)
- Canada Research Chairs program
- CREATE Sustainable Synthesis
- University of British Columbia
Hydroaminoalkylation is a 100% atom economic method for forming C-sp(3)-C-sp(3) bonds through C-H activation to an amine and subsequent reaction with an alkene. When catalyzed by early transition metals, this reaction allows for alternative disconnections for the synthesis of structurally complex amines. This method avoids the installation of protecting groups or directing groups and does not require added oxidants, or photoredox catalysts. In this feature article, we discuss the various selectively substituted amines that can be accessed by hydroaminoalkylation, with a special focus on the development of early transition metal catalysts for their rapid, step and atom efficient assembly.
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