Alkylarylation of styrenes via direct C(sp(3))-Br/C(sp(2))-H functionalization mediated by photoredox and copper cooperative catalysis

For straightforward access to various substituted 1,1-diarylalkanes a photoredox-catalyzed and copper-promoted 1,2-alkylarylation reaction of styrenes has been developed, which uses -carbonyl alkyl bromides and N,N-disubstituted anilines as functionalization reagents. In this radical difunctionalization reaction, -carbonyl alkyl bromides, including primary-, secondary- and tertiary--bromoalkyl ketone esters, malonic esters and cycloalkane were transformed to the corresponding 1,1-diarylalkanes in moderate to good yields at room temperature. Notably, this transformation provided a new route for the C-H alkylation of N,N-disubstituted anilines with high para-selectivity beyond the typical Friedel-Crafts alkylation.