期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 5, 页码 1162-1184出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201704745
关键词
chemical biology; chemical probes; epigenetics; lysine acetyltransferases; post-translational modifications
资金
- National Science Foundation [1507741]
- American Heart Association [12GRNT12070056]
The side-chain acetylation of lysine residues in histones and non-histone proteins catalyzed by lysine acetyltransferases (KATs) represents a widespread posttranslational modification (PTM) in the eukaryotic cells. Lysine acetylation plays regulatory roles in major cellular pathways inside and outside the nucleus. In particular, KAT-mediated histone acetylation has an effect on all DNA-templated epigenetic processes. Aberrant expression and activation of KATs are commonly observed in human diseases, especially cancer. In recent years, the study of KAT functions in biology and disease has greatly benefited from chemical biology tools and strategies. In this Review, we present the past and current accomplishments in the design of chemical biology approaches for the interrogation of KAT activity and function. These methods and probes are classified according to their mechanisms of action and respective applications, with both strengths and limitations discussed.
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