期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 2, 页码 437-441出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201710835
关键词
bromoallenes; C-H activation; Lewis acids; manganese; propargylation
资金
- Alexander von Humboldt Foundation
- Alfried Krupp von Bohlen and Halbach Foundation
A manganese(I)/Lewis acid cocatalyzed direct C-H propargylation with high selectivity has been developed. BPh3 was discovered to not only promote the reactivity, but also enhance the selectivity. Secondary, tertiary, and even quaternary carbon centers at the propargylic position could be directly constructed. Both internal and terminal alkynes are easily accessible. The chirality was successfully transferred from an axially chiral allene to central chirality. The reactivity of the manganese catalyst in this reaction was found to be unique among transition metal catalysts.
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