期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 3, 页码 594-598出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201705728
关键词
cleavage reactions; iminyl radicals; microwave chemistry; radical traps; ring-distortion
资金
- American Chemical Society Petroleum Research Fund [55514-ND1]
- Brigham Young University
The synthesis of functionalized nitriles via microwave-promoted radical fragmentations of cyclic O-phenyl oxime ethers is reported. A variety of radical traps can be employed, permitting the generation of diverse adducts via C-O, C-C, C-N, or C-X bond formation. Other salient features include a simple and practical protocol, very short reaction times, and the avoidance of metal catalysts and toxic cyanide reagents. The utility of this method is demonstrated by the ring-distortion of a steroid-derived substrate.
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