期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 1, 页码 177-181出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201709648
关键词
aspirin; graphitic nanocapsules; inflammation; photothermal therapy; prodrugs
资金
- National Natural Science Foundation of China [21522501, 21521063, 31701249]
- Keypoint Research and Invention Program of Hunan Province [2017DK2011]
- Science and Technology Development Fund of Macao S.A.R. (FDCT) [067/2014/A, 097/2015/A3]
Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was developed to deliver enhanced PTT and simultaneously inhibit PTT-induced inflammatory response. 1-Pyrene methanol was utilize to synthesize the anti-inflammatory prodrug pyrene-aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the prodrug on gold nanorod (AuNR)-encapsulated graphitic nanocapsule (AuNR@G), a photothermal agent, through pi-pi interactions. Such AuNR@G-P-aspirin complexes were used for near-infrared laser-triggered photothermal ablation of solid tumor and simultaneous inhibition of PTT-induced inflammation through the release of aspirin in tumor milieu. This strategy showed excellent effects invitro and in vivo.
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