期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 18, 期 1, 页码 53-62出版社
WILEY
DOI: 10.1111/ajt.14399
关键词
translational research; science; basic (laboratory) research; science; kidney transplantation; nephrology; pathology; histopathology; kidney failure; injury; ischemia reperfusion injury (IRI); autotransplantation; organ perfusion and preservation; surgical technique
资金
- Astellas Pharma Europe
- Novartis
Robot-assisted kidney transplantation is feasible; however, concerns have been raised about possible increases in warm ischemia times. We describe a novel intra-abdominal cooling system to continuously cool the kidney during the procedure. Porcine kidneys were procured by standard open technique. Groups were as follows: Robotic renal transplantation with (n = 11) and without (n = 6) continuous intra-abdominal cooling and conventional open technique with intermittent 4 degrees C saline cooling (n = 6). Renal cortex temperature, magnetic resonance imaging, and histology were analyzed. Robotic renal transplantation required a longer anastomosis time, either with or without the cooling system, compared to the open approach (70.4 +/- 17.7 min and 74.0 +/- 21.5 min vs. 48.7 +/- 11.2 min, p-values < 0.05). The temperature was lower in the robotic group with cooling system compared to the open approach group (6.5 +/- 3.1 degrees C vs. 22.5 +/- 6.5 degrees C; p = 0.001) or compared to the robotic group without the cooling system (28.7 +/- 3.3 degrees C; p < 0.001). Magnetic resonance imaging parenchymal heterogeneities and histologic ischemia-reperfusion lesions were more severe in the robotic group without cooling than in the cooled (open and robotic) groups. Robot-assisted kidney transplantation prolongs the warm ischemia time of the donor kidney. We developed a novel intra-abdominal cooling system that suppresses the noncontrolled rewarming of donor kidneys during the transplant procedure and prevents ischemia-reperfusion injuries.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据