期刊
BIOPHYSICAL JOURNAL
卷 105, 期 8, 页码 1805-1811出版社
CELL PRESS
DOI: 10.1016/j.bpj.2013.09.005
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Biochemical signaling pathways in developmental processes have been extensively studied, yet the role of mechanical cues during embryogenesis is much less explored. Here we have used selective plane illumination microscopy in com-bination with a simple mechanical model to quantify and rationalize cell motion during early embryogenesis of the small nematode Caenorhabditis elegans. As a result, we find that cell organization in the embryo until gastrulation is well described by a purely mechanical model that predicts cells to assume positions in which they face the least repulsive interactions from other cells and the embryo's egg shell. Our findings therefore suggest that mechanical interactions are key for a rapid and robust cellular arrangement during early embryogenesis of C. elegans.
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