期刊
DATA IN BRIEF
卷 20, 期 -, 页码 1877-1883出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dib.2018.09.044
关键词
Alzheimer's disease; Angiogenesis; Novel object cognition test; Spatial memory; Spontaneous physical activity; Non-spatial memory
资金
- JSPS KAKENHI [JP26462161, JP24590133, JP15K07910, JP16K08336]
We herein present behavioral data regarding whether COA-Cl, a novel adenosine-like nucleic acid analog that promotes angiogenesis and features neuroprotective roles, improves cognitive and behavioral deficits in a murine model for Alzheimer's disease (AD). COA-CI induced significant spatial memory improvement in the amyloid precursor protein/presenilin 2 double-transgenic mouse model of AD (PS2Tg2576 mice). Correspondingly, non-spatial novel object cognition test performance also significantly improved in COA-Cl-treated PS2Tg2576 mice; however, these mice demonstrated no significant changes in physical activity or motor performance. COA-CI did not change the spontaneous activities and cognitive ability in the wild-type mice. (C) 2018 The Authors. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据