期刊
BIOPHYSICAL JOURNAL
卷 102, 期 11, 页码 2510-2516出版社
CELL PRESS
DOI: 10.1016/j.bpj.2012.04.041
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类别
资金
- European Union [21204]
- Spanish Ministerio de Ciencia e Innovacion [BFU 2007-62062, BFU 201128566]
- University of the Basque Country [Giv 06/42]
It has been repeatedly observed that lipid bilayers in the gel phase are solubilized by lower concentrations of Triton X-100, at least within certain temperature ranges, or other nonionic detergents than bilayers in the fluid phase. In a previous study, we showed that detergent partition coefficients into the lipid bilayer were the same for the gel and the fluid phases. In this contribution, turbidity, calorimetry, and P-31-NMR concur in showing that bilayers in the gel state ( at least down to 13-20 degrees C below the gel-fluid transition temperature) become saturated with detergent at lower detergent concentrations than those in the fluid state, irrespective of temperature. The different saturation may explain the observed differences in solubilization.
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