期刊
ADVANCED FUNCTIONAL MATERIALS
卷 28, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201700232
关键词
brain; electrocorticography; electrodes; humans; poly(3,4-ethylenedioxythiophene) (PEDOT)
类别
资金
- Center for Brain Activity Mapping (CBAM) at UC San Diego
- Department of Electrical and Computer Engineering at UC San Diego
- NSF [ECCS-1351980]
- University of California Multicampus Research Programs and Initiatives (UC MRPI) [MR-15-328909]
- Office of Naval Research [N00014-13-1-0672]
- Directorate For Engineering [1351980] Funding Source: National Science Foundation
Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal-to-noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based interfaces surpass those of current clinical electrocorticography electrodes. Here, robust fabrication process of PEDOT:PSS microelectrode arrays is demonstrated for safe and high fidelity intraoperative monitoring of human brain. PEDOT:PSS microelectrodes measure significant differential neural modulation under various clinically relevant conditions. This study reports the first evoked (stimulus-locked) cognitive activity with changes in amplitude across pial surface distances as small as 400 mu m, potentially enabling basic neurophysiology studies at the scale of neural micro-circuitry.
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