期刊
DIABETOLOGIA
卷 61, 期 1, 页码 29-38出版社
SPRINGER
DOI: 10.1007/s00125-017-4435-8
关键词
Animal models; Diabetic retinopathy; Neurovascular unit; Review; Vasoregression
资金
- European Foundation for the Study of Diabetes (EFSD)
- Deutsche Forschungsgemeinschaft [DFG: GRK 880, GRK 1874/1, GRK 1874/2, SFB 1118, DFG Ha 1755/1-10]
- German Diabetes Association
- JDRF
- European Union
Diabetic retinopathy remains a relevant clinical problem. In parallel with diagnostic and therapeutic improvements, the role of glycaemia and reactive metabolites causing cell stress and biochemical abnormalities as treatment targets needs continuous re-evaluation. Furthermore, the basic mechanisms of physiological angiogenesis, remodelling and pruning give important clues about the origins of vasoregression during the very early stages of diabetic retinopathy and can be modelled in animals. This review summarises evidence supporting a role for the neurovascular unit-composed of neuronal, glial and vascular cells-as a responder to the biochemical changes imposed by reactive metabolites and high glucose. Normoglycaemic animal models developing retinal degeneration, provide valuable information about common pathways downstream of progressive neuronal damage that induce vasoregression, as in diabetic models. These models can serve to assess novel treatments addressing the entire neurovascular unit for the benefit of early diabetic retinopathy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据