期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 42, 页码 7774-7781出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob01929k
关键词
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资金
- EPSRC [EP/L015633/1]
- GlaxoSmithKline
The Mitsunobu reaction is widely regarded as the pre-eminent method for performing nucleophilic substitutions of alcohols with inversion of configuration. However, its applicability to large-scale synthesis is undermined by the fact that alcohol activation occurs at the expense of two stoichiometric reagents - a phosphine and an azodicarboxylate. The ideal Mitsunobu reaction would be sub-stoichiometric in the phosphine and azodicarboxylate species and employ innocuous terminal oxidants and reductants to achieve recycling. This Review article provides a summary and analysis of recent advances towards the development of such catalytic Mitsunobu reactions.
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