期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 44, 页码 8434-8445出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob02157k
关键词
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资金
- National Key Research and Development Program of China [2017YFA0505200]
- National Science Foundation of China [81222042, 81573264, 21402118]
- Science Foundation of Shanghai [17ZR1449000]
- E-Institutes of Shanghai Universities (EISU) Chemical Biology Division
Molecular photoswitches are a class of chemical structures that can readily isomerize between distinct geometries upon irradiation with light. Molecular photoswitches are utilized to control protein structure and function with temporal and spatial precision. In this review, we summarize the recent progress in the development of azobenzene-based molecular photoswitches and their applications in the photocontrol of protein structure and function. For clarity of discussion, we divide the known photoswitchable proteins into different categories: protein motifs, ion channels, receptors, and enzymes. Basic approaches and considerations for the structure-guided design of photoswitchable ligands are discussed. The applications and limitations of current photoswitches are also discussed.
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