期刊
BIOPHYSICAL JOURNAL
卷 103, 期 2, 页码 352-356出版社
CELL PRESS
DOI: 10.1016/j.bpj.2012.06.008
关键词
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类别
资金
- National Institutes of Health [R01HG003703]
- National Science Foundation [ECS-0335765]
We demonstrate that voltage-biased solid-state nanopores can transiently localize DNA in an electrolyte solution. A double-stranded DNA (dsDNA) molecule is trapped when the electric field near the nanopore attracts and immobilizes a non-end segment of the molecule across the nanopore orifice without inducing a folded molecule translocation. In this demonstration of the phenomenon, the ionic current through the nanopore decreases when the dsDNA molecule is trapped by the nanopore. By contrast, a translocating dsDNA molecule under the same conditions causes an ionic current increase. We also present finite-element modeling results that predict this behavior for the conditions of the experiment.
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