期刊
BIOPHYSICAL JOURNAL
卷 100, 期 8, 页码 L37-L39出版社
CELL PRESS
DOI: 10.1016/j.bpj.2011.03.007
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资金
- National Institutes of Health [GM 40871, GM65830]
- National Natural Science Foundation of China [30970970]
- Specialized Research Fund for the Doctoral Program of Higher Education [20090121110028]
A new mechanism of cell-cell communication was recently proposed after the discovery of tunneling nanotubes (TNTs) between cells. TNTs are membrane protrusions with lengths of tens of microns and diameters of a few hundred nanometers that permit the exchange of membrane and cytoplasmic constituents between neighboring cells. TNTs have been reported to mediate intercellular Ca2+ signaling; however, our simulations indicate that passive diffusion of Ca2+ ions alone would be inadequate for efficient transmission between cells. Instead, we observed spontaneous and inositol trisphosphate (IP3)-evoked Ca2+ signals within TNTs between cultured mammalian cells, which sometimes remained localized and in other instances propagated as saltatory waves to evoke Ca2+ signals in a connected cell. Consistent with this, immunostaining showed the presence of both endoplasmic reticulum and IP3 receptors along the TNT. We propose that IP3 receptors may actively propagate intercellular Ca2+ signals along TNTs via Ca2+-induced Ca2+ release, acting as amplification sites to overcome the limitations of passive diffusion in a chemical analog of electrical transmission of action potentials.
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