期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 6, 期 43, 页码 6969-6976出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8tb01874j
关键词
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资金
- National Basic Research Foundation (973) of China [2014CB932004]
- National Key R&D Program of China [2017YFA02073022]
- National Natural Science Foundation of China [21101131, 21731005, 21420102001, 21721001]
- Natural Science Foundation of Fujian Province [2016J01073]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR 2018-B10]
In this work, a novel nanoplatform based on Pd corolla-human serum albumin-indocyanine green (PdCs-HSA-ICG) was developed for cancer photothermal/photodynamic combination therapy. Pd corollas (denoted as PdCs) with good near-infrared photothermal conversion efficiency ( approximate to 37%) were first prepared and modified with human serum albumin (HSA) and indocyanine green (ICG) to get the PdCs-HSA-ICG nanocomposite. The prepared PdCs-HSA-ICG not only improves the colloid and thermal stability of ICG, but also shows a higher temperature increase than that of PdCs and free ICG as well as a comparable singlet oxygen (O-1(2)) generation capability to that of free ICG. Upon single 808 nm laser irradiation, the photothermal (PTT)/photodynamic (PDT) combined therapeutic efficacy of PdCs-HSA-ICG at both cellular and animal levels was superior to PdCs-HSA (PTT) or free ICG (PTT and PDT), respectively. Thus, the designed PdCs-HSA-ICG nanocomposite holds great potential as a new class of photosensitive agent for cancer phototherapy.
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