期刊
CLINICAL INFECTIOUS DISEASES
卷 66, 期 1, 页码 11-19出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cix733
关键词
OPAT; adverse drug events; vancomycin; antibiotic side effect; drug monitoring
资金
- National Center for Advancing Translational Sciences/Johns Hopkins Institute for Clinical and Translational Research [KL2TR001077]
- Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases Discovery award
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [KL2TR001077] Funding Source: NIH RePORTER
Background. To better monitor patients on outpatient parenteral antimicrobial therapy (OPAT), we need an improved understanding of risk factors for and timing of OPAT-associated adverse drug events (ADEs). Methods. We analyzed a prospective cohort of patients on OPAT discharged from 2 academic medical centers. Patients underwent chart abstraction and a telephone survey. Multivariable analyses estimated adjusted incident rate ratios (aIRR) between clinical and demographic risk factors and clinician-determined clinically significant ADEs. Descriptive data were used to present patient-reported ADEs. Results. Of 339 patients enrolled in the study, 18.0% experienced an ADE (N = 65), of which 49 were significant (14.5%, 2.24/1000 home-OPAT days). Patients with longer courses of therapy had lower rates of ADEs compared with patients treated for 0-13 days (14-27 days: aIRR, 0.44; 95% confidence interval [CI], 0.20-0.99; at least 28 days: aIRR, 0.11; 95% CI, 0.056-0.21). Risk factors for ADEs included female gender and receipt of daptomycin or vancomycin, while treatment for uncomplicated bacteremia and empiric treatment were associated with lower rates of ADEs. Conclusions. OPAT-related ADEs were common and often occurred within 2 weeks of hospital discharge. Patients on OPAT should be monitored more closely for ADEs, including clinical assessment and laboratory monitoring, especially within the first weeks after hospital discharge and particularly among women and patients who receive vancomycin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据