Combining Noise-to-Image and Image-to-Image GANs: Brain MR Image Augmentation for Tumor Detection

Convolutional Neural Networks (CNNs) achieve excellent computer-assisted diagnosis with sufficient annotated training data. However, most medical imaging datasets are small and fragmented. In this context, Generative Adversarial Networks (GANs) can synthesize realistic/diverse additional training images to fill the data lack in the real image distribution; researchers have improved classification by augmenting data with noise-to-image (e.g., random noise samples to diverse pathological images) or image-to-image GANs (e.g., a benign image to a malignant one). Yet, no research has reported results combining noise-to-image and image-to-image GANs for further performance boost. Therefore, to maximize the DA effect with the GAN combinations, we propose a two-step GAN-based DA that generates and refines brain Magnetic Resonance (MR) images with/without tumors separately: (${i}$ ) Progressive Growing of GANs (PGGANs), multi-stage noise-to-image GAN for high-resolution MR image generation, first generates realistic/diverse $256\times 256$ images; (ii) Multimodal UNsupervised Image-to-image Translation (MUNIT) that combines GANs/Variational AutoEncoders or SimGAN that uses a DA-focused GAN loss, further refines the texture/shape of the PGGAN-generated images similarly to the real ones. We thoroughly investigate CNN-based tumor classification results, also considering the influence of pre-training on ImageNet and discarding weird-looking GAN-generated images. The results show that, when combined with classic DA, our two-step GAN-based DA can significantly outperform the classic DA alone, in tumor detection (i.e., boosting sensitivity 93.67 to 97.48) and also in other medical imaging tasks.