期刊
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
卷 17, 期 -, 页码 1151-1161出版社
ELSEVIER
DOI: 10.1016/j.csbj.2019.07.021
关键词
Endothelial; Hepatocyte; Genetic; Nutrient sensing pathways; Mitochondrial dysfunction; Senescence
资金
- Australian National Health and Medical Research Council [1141234]
- Aging and Alzheimer's Research Foundation (Division of the Medical Foundation of the University of Sydney)
- Sydney Medical School Foundation McKnight Bequest
- University of Sydney DVCR Research Equity Fellowship
While the liver demonstrates remarkable resilience during aging, there is growing evidence that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and systemic disease. The aging process in the liver is driven by alterations of the genome and epigenome that contribute to dysregulation of mitochondrial function and nutrient sensing pathways, leading to cellular senescence and low-grade inflammation. These changes promote multiple phenotypic changes in all liver cells (hepatocytes, liver sinusoidal endothelial, hepatic stellate and Kilpffer cells) and impairment of hepatic function. In particular, age-related changes in the liver sinusoidal endothelial cells are a significant but under-recognized risk factor for the development of age-related cardiometabolic disease. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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