期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 6, 期 4, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2019.1604047
关键词
Cancer therapy; G-quadruplex; autophagy; DNA damage response; senescence
类别
资金
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- University of Bordeaux
- Institut Curie
- Bergonie Institute
- Conseil Regional d'Aquitaine
- Ligue contre le Cancer
- Comite de Dordogne
- SYMBIT project - ERDF [CZ.02.1.01/0.0/0.0/15_003/0000477]
G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.
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