Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study

Introduction: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease. Methods: Cross-sectional regression analyses were performed in Framingham Heart Study Third Generation (n=1861) and Offspring (n=909) cohort participants assessing the association of accelerometry-measured PA with cognitive function, adjusting for age, sex, accelerometer wear time, education, occupational status/PA, and smoking status. Results: In each cohort, achieving just 10-21.4min/day moderate-to-vigorous PA related to better executive function (P<.02); and just 10min/day moderate-to-vigorous PA was associated with better verbal memory in middle-aged adults in the Third Generation cohort (P=.02). In older adults of the Offspring cohort, total PA (measured in steps/day) was associated with better executive function (P<.02). Discussion: PA at levels lower than the current PA Guidelines (just 10min/day moderate-to-vigorous PA and total PA including lower intensity PA) were associated with better cognitive function. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.