期刊
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
卷 5, 期 1, 页码 618-626出版社
WILEY
DOI: 10.1016/j.trci.2019.08.007
关键词
Cognition; Executive function; Memory; Physical activity; Exercise; Accelerometer; Moderate-to-vigorous; Sedentary time; Epidemiology
资金
- Framingham Heart Study's National Heart, Lung and Blood Institute [N01-HC25195, HHSN268201500001I, 75N92019D00031]
- National Institutes of Health [R01-AG054076, R01-AG049607, R01-AG047645, R01-HL131029, R01-AG0081220, R01-AG031287, R01 AG033040, R01 NS017950, UH2 NS100605]
- Alzheimer's Association [2018-AARG-591645]
- American Heart Association [15GPSGC24800006, 16MCPRP30310001]
- Evans Medical foundation
- Jay and Louis Coffman Endowment, Department of Medicine, BUSM
Introduction: Physical activity (PA) may play a role in maintenance of cognitive function in both middle and older ages and prevention of outcomes such as dementia and Alzheimer's disease. Methods: Cross-sectional regression analyses were performed in Framingham Heart Study Third Generation (n=1861) and Offspring (n=909) cohort participants assessing the association of accelerometry-measured PA with cognitive function, adjusting for age, sex, accelerometer wear time, education, occupational status/PA, and smoking status. Results: In each cohort, achieving just 10-21.4min/day moderate-to-vigorous PA related to better executive function (P<.02); and just 10min/day moderate-to-vigorous PA was associated with better verbal memory in middle-aged adults in the Third Generation cohort (P=.02). In older adults of the Offspring cohort, total PA (measured in steps/day) was associated with better executive function (P<.02). Discussion: PA at levels lower than the current PA Guidelines (just 10min/day moderate-to-vigorous PA and total PA including lower intensity PA) were associated with better cognitive function. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
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