4.1 Review

Emerging targets in cancer drug resistance

期刊

CANCER DRUG RESISTANCE
卷 2, 期 2, 页码 161-177

出版社

OAE PUBLISHING INC
DOI: 10.20517/cdr.2018.27

关键词

Drug resistance; transforming growth factor-beta; Keap1-Nrf2; PI3K-Akt; FOXO transcription factors; focal adhesion kinases; annexins; MIEN1; gene splicing; sphingolipids; microRNA

类别

资金

  1. Department of Defense [W81XWH-18-1-0618, W81XWH-15-1-0558]
  2. VA Merit Review [1I01BX002494]
  3. University Grants Commission, India
  4. Department of Science and Technology, India [EEQ/2016/000350]
  5. University Grants Commission, India [F.30-372/2017 (BSR)]

向作者/读者索取更多资源

Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer treatment. Malignant cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and pathways. Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes. This review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance.

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