期刊
CANCER DRUG RESISTANCE
卷 2, 期 2, 页码 161-177出版社
OAE PUBLISHING INC
DOI: 10.20517/cdr.2018.27
关键词
Drug resistance; transforming growth factor-beta; Keap1-Nrf2; PI3K-Akt; FOXO transcription factors; focal adhesion kinases; annexins; MIEN1; gene splicing; sphingolipids; microRNA
类别
资金
- Department of Defense [W81XWH-18-1-0618, W81XWH-15-1-0558]
- VA Merit Review [1I01BX002494]
- University Grants Commission, India
- Department of Science and Technology, India [EEQ/2016/000350]
- University Grants Commission, India [F.30-372/2017 (BSR)]
Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer treatment. Malignant cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and pathways. Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes. This review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance.
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