期刊
BIOPHYSICAL JOURNAL
卷 100, 期 6, 页码 1400-1409出版社
CELL PRESS
DOI: 10.1016/j.bpj.2011.01.038
关键词
-
类别
资金
- French National Agency of Research
- Human Frontier Science Program grant
- MIT-France
- ICAM (Institute for Complex Adaptative Matter)
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [844115] Funding Source: National Science Foundation
Reconstituted systems mimicking cells are interesting tools for understanding the details of cell behavior. Here, we use an experimental system that mimics cellular actin cortices, namely liposomes developing an actin shell close to their inner membrane, and we study their dynamics of spreading. We show that depending on the morphology of the actin shell inside the liposome, spreading dynamics is either reminiscent of a bare liposome (in the case of a sparse actin shell) or of a cell (in the case of a continuous actin shell). We use a mechanical model that qualitatively accounts for the shape of the experimental curves. From the data on spreading dynamics, we extract characteristic times that are consistent with mechanical estimates. The mechanical characterization of such stripped-down experimental systems paves the way for a more complex design closer to a cell. We report here the first step in building an artificial cell and studying its mechanics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据