期刊
COMPREHENSIVE PHYSIOLOGY
卷 9, 期 1, 页码 207-299出版社
WILEY
DOI: 10.1002/cphy.c180015
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资金
- National Institutes of Health [R01GM120774, R01HL098215, L40HL097863, R01AG049821, R00HL124142]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R00HL124142] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM120774] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG049821] Funding Source: NIH RePORTER
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body. The lymphatic system maintains extracellular fluid homeostasis favorable for optimal tissue function, removing substances that arise due to metabolism or cell death, and optimizing immunity against bacteria, viruses, parasites, and other antigens. This article provides a comprehensive review of important findings over the past century along with recent advances in the understanding of the anatomy and physiology of lymphatic vessels, including tissue/organ specificity, development, mechanisms of lymph formation and transport, lymphangiogenesis, and the roles of lymphatics in disease. (c) 2019 American Physiological Society.
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