期刊
BIOPHYSICAL JOURNAL
卷 98, 期 5, 页码 824-833出版社
CELL PRESS
DOI: 10.1016/j.bpj.2009.10.054
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资金
- Agence Nationale de Recherche sur le Syndrome d'rainuno Deficience Acquise et les Hepatites Virales
- Genopole Evry. France
- Agence Nationale de Recherche [05-NANO-062-03]
During eukaryotic transcription, RNA-polymerase activity generates torsional stress in DNA, having a negative impact on the elongation process. Using our previous studies of chromatin fiber structure and conformational transitions, we suggest that this torsional stress can be alleviated, thanks to a tradeoff between the fiber twist and nucleosome conformational transitions into an activated state named reversome. Our model enlightens the origin of polymerase pauses, and leads to the counterintuitive conclusion that chromatin-organized compaction might facilitate polymerase progression. Indeed, in a compact and well-structured chromatin loop, steric hindrance between nucleosomes enforces sequential transitions, thus ensuring that the polymerase always meets a permissive nucleosomal state.
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