期刊
BIOPHYSICAL JOURNAL
卷 99, 期 4, 页码 1091-1100出版社
CELL PRESS
DOI: 10.1016/j.bpj.2010.06.025
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资金
- National Science Foundation [DMR-0602684, CTS-0505929]
- Harvard Materials Research Science and Engineering Center [DMR-0820484]
- Harvard University Science and Engineering Committee
- National Defense Science and Engineering Graduate Fellowship
- Foundation for Fundamental Research on Matter/The Netherlands Organisation for Scientific Research
- National Institutes of Health [HL-19429]
- European Marie Curie grant [FP6-2002-Mobility-6B]
- National Heart, Lung, and Blood Institute of the National Institutes of Health [1 F33 HL083684-01]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [820484] Funding Source: National Science Foundation
Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers.
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