期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 32, 页码 7213-7224出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00768d
关键词
-
资金
- National Natural Science Foundation of China [31871017, 81573234]
- Natural Science Foundation of Jiangsu Province, China [BK20171352]
- Medical Science and Technology Development Foundation
- Jiangsu Provincial Commission of Health and Family Planning, China [ZDRCA2016073]
- Southeast University-Nanjing Medical University Cooperative research project [2242019K3DN05]
- 111 Project [B17011]
The field of cardiac tissue engineering has made significant strides in therapeutic and pharmaceutical applications, highlighted by the development of smart biomaterials. Scaffolds with appropriate properties mimicking the nature of a heart matrix will be highly beneficial for cardiac tissue engineering. In this study, high-aspect-ratio water-dispersed gold nanowires (AuNWs) were synthesized and incorporated into gelatin methacrylate (GelMA) hydrogels, demonstrating enhanced electrical conductivity and mechanical properties of the biomaterial scaffolds. Cardiac cells cultured on GelMA-AuNW hybrid hydrogels exhibited better biological activities such as cell viability and maturation state compared to those cultured on GelMA hydrogels. Moreover, cardiomyocytes showed synchronous beating activity and a faster spontaneous beating rate on GelMA-AuNW hybrid hydrogels. Our strategy of integrating high-aspect-ratio water-dispersed gold nanowires within gelatin methacrylate hydrogels provides a favorable biomaterial scaffold to construct functional cardiac tissue for further applications in cardiac tissue engineering and drug screening.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据