期刊
THERANOSTICS
卷 10, 期 22, 页码 10031-10045出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.49008
关键词
Biofilm; polyoxometalate; acid/reductive-responsive; peroxidase-like activity; photothermal antibacterial effect
资金
- National Natural Science Foundation of China [31901005]
- Sichuan Science and Technology Program [2018RZ0134]
- Special Foundation for Basic Scientific Research Operations of Central Universities [2019NYB15]
- Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS [NSKF201815]
Backgroud: Nowadays, biofilms that are generated as a result of antibiotic abuse cause serious threats to global public health. Such films are the primary factor that contributes to the failure of antimicrobial treatment. This is due to the fact that the films prevent antibiotic infiltration, escape from innate immune attacks by phagocytes and consequently generate bacterial resistance. Therefore, exploiting novel antibacterial agents or strategies is extremely urgent. Methods: Herein, we report a rational construction of a novel biofilm microenvironment (BME)-responsive antibacterial platform that is based on tungsten (W)-polyoxometalate clusters (POMs) to achieve efficient bactericidal effects. Results: On one hand, the acidity and reducibility of a BME could lead to the self-assembly of POMs to produce large aggregates, which favor biofilm accumulation and enhance photothermal conversion under near-infrared (NIR) light irradiation. On the other hand, reduced POM aggregates with BME-induced photothermal-enhanced efficiency also exhibit surprisingly high peroxidase-like activity in the catalysis of bacterial endogenous hydrogen peroxide (H2O2) to produce abundant reactive oxygen species (ROS). This enhances biofilm elimination and favors antibacterial effects. Most importantly, reduced POMs exhibit the optimal peroxidase-like activity in an acidic BME. Conclusion: Therefore, in addition to providing a prospective antibacterial agent, intelligent acid/reductive dual-responsive POMs will establish a new representative paradigm for the areas of healthcare with minimal side effects.
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