期刊
THERANOSTICS
卷 10, 期 18, 页码 8315-8342出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.45922
关键词
SIRT3; Mitochondrial homeostasis; Age-related disease; Cancer; SIRT3 activator; SIRT3 inhibitor
资金
- National Natural Science Foundation of China [81673455, 81803365, 81573290, U1603123]
- Post-Doctor Research Project [2018M643510]
- West China Hospital, Sichuan University [2018HXBH065]
- Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y036]
- GDUPS (2019), National Science and Technology Major Project of the Ministry of Science and Technology of China [2018ZX09735005]
Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism of multiple organs. Hitherto, SIRT3 has been substantiated to be involved in almost all aspects of mitochondrial metabolism and homeostasis, protecting mitochondria from a variety of damage. Accumulating evidence has recently documented that SIRT3 is associated with many types of human diseases, including age-related diseases, cancer, heart disease and metabolic diseases, indicating that SIRT3 can be a potential therapeutic target. Here we focus on summarizing the intricate mechanisms of SIRT3 in human diseases, and recent notable advances in the field of small-molecule activators or inhibitors targeting SIRT3 as well as their potential therapeutic applications for future drug discovery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据