期刊
BIOPHYSICAL JOURNAL
卷 96, 期 3, 页码 785-797出版社
CELL PRESS
DOI: 10.1016/j.bpj.2008.09.053
关键词
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类别
资金
- National Science Foundation [MCB-0615469]
The amyloid-beta (A beta) peptide is a key aggregate species in Alzheimer's disease. Although important aspects of A beta peptide aggregation are understood, the initial stage of aggregation from monomer to oligomer is still not clear. One potential mediator of this early aggregation process is interactions of A beta with anionic cell membranes. We used unconstrained and umbrella sampling molecular dynamics simulations to investigate interactions between the 42-amino acid A beta peptide and model bilayers of zwitterionic dipalmitoylphosphatidylcholine (DPPC) lipids and anionic dioleoylphosphatidylserine (DOPS) lipids. Using these methods, we determined that A beta is attracted to the surface of DPPC and DOPS bilayers over the small length scales used in these simulations. We also found supporting evidence that the charge on both the bilayer surface and the peptide affects the free energy of binding of the peptide to the bilayer surface and the distribution of the peptide on the bilayer surface. Our work demonstrates that interactions between the A beta peptide and lipid bilayer promotes a peptide distribution on the bilayer surface that is prone to peptide-peptide interactions, which can influence the propensity of A beta to aggregate into higher-order structures.
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