期刊
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
卷 14, 期 5, 页码 1149-1151出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dsx.2020.06.060
关键词
Body mass index; COVID-19; Obesity
资金
- British Heart Foundation Research Excellence Award [RE/18/6/34217]
- MMI -Kuwait and Dasman Diabetes Institute, Kuwait
- NRS Senior Clinical Fellowship [SCAF/15/02]
- Medical Research Council [MC_UU_12017/13]
- Scottish Government Chief Scientist Office [SPHSU13]
- MRC [MC_UU_12017/13, MC_UU_00022/2] Funding Source: UKRI
Aims: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants. Methods: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors. Results: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (P-interaction = 0.03). BMI was more strongly related to test positivity (P-interaction = 0.010) and death (P-interaction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites. Conclusions: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities. (c) 2020 The Authors. Published by Elsevier Ltd on behalf of Diabetes India.
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