期刊
BIOPHYSICAL JOURNAL
卷 96, 期 4, 页码 L32-L34出版社
CELL PRESS
DOI: 10.1016/j.bpj.2008.12.3760
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类别
资金
- National Institutes of Health [R01 HG003713A, P41-RR05969, CA65145]
- National Science Foundation [TH 2008-01040]
- Division Of Physics
- Direct For Mathematical & Physical Scien [0822613] Funding Source: National Science Foundation
Methylation of cytosine is a covalent modification of DNA that can be used to silence genes, orchestrating a myriad of biological processes including cancer. We have discovered that a synthetic nanopore in a membrane comparable in thickness to a protein binding site can be used to detect methylation. We observe a voltage threshold for permeation of methylated DNA through a <2 nm diameter pore, which we attribute to the stretching transition; this can differ by > 1 V/20 nm depending on the methylation level, but not the DNA sequence.
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