期刊
NEUROIMAGE-CLINICAL
卷 25, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2019.102138
关键词
Idiopathic REM behavior disorder; Resting state fMRI; Graph; Parkinson's disease; Connectome; Cognition
类别
资金
- Spanish Ministry of Economy and Competitiveness [BES-2014-068173, PSI2017-86930-P]
- Agencia Estatal de Investigacion (AEI)
- European Regional Development Fund
- Generalitat de Catalunya [2017SGR 748]
- Fundacio La Marato de TV3 in Spain [20142310]
- APIF predoctoral fellowship from the University of Barcelona
- Departament d'Empresa i Coneixement de la Generalitat de Catalunya
- AGAUR [2016FI_B 00360, 2017FI_B1 00013, 2018FI_B2 00001]
- European Social Fund (ESF)
Background: Resting-state functional MRI has been proposed as a new biomarker of prodromal neurodegenerative disorders, but it has been poorly investigated in the idiopathic form of rapid-eye-movement sleep behavior disorder (IRBD), a clinical harbinger of subsequent synucleinopathy. Particularly, a complex-network approach has not been tested to study brain functional connectivity in IRBD patients. Objectives: The aim of the current work is to characterize resting-state functional connectivity in IRBD patients using a complex-network approach and to determine its possible relation to cognitive impairment. Method: Twenty patients with IRBD and 27 matched healthy controls (HC) underwent resting-state functional MRI with a 3T scanner and a comprehensive neuropsychological battery. The functional connectome was studied using threshold-free network-based statistics. Global and local network parameters were calculated based on graph theory and compared between groups. Head motion, age and sex were introduced as covariates in all analyses. Results: IRBD patients showed reduced cortico-cortical functional connectivity strength in comparison with HC in edges located in posterior regions (p <0.05, FWE corrected). This regional pattern was also shown in an independent analysis comprising posterior areas where a decreased connectivity in 51 edges was found, whereas no significant results were detected when an anterior network was considered (p <0.05, FWE corrected). In the posterior network, the left superior parietal lobule had reduced centrality in IRBD. Functional connectivity strength between left inferior temporal lobe and right superior parietal lobule positively correlated with mental processing speed in IRBD (r = .633; p = .003). No significant correlations were found in the HC group. Conclusion: Our findings support the presence of disrupted posterior functional brain connectivity of IRBD patients similar to that found in synucleinopathies. Moreover, connectivity reductions in IRBD were associated with lower performance in mental processing speed domain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据