期刊
BIOPHYSICAL JOURNAL
卷 96, 期 5, 页码 1691-1706出版社
CELL PRESS
DOI: 10.1016/j.bpj.2008.10.066
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资金
- NIAID NIH HHS [R01 AI051575-06A2, R01 AI051575] Funding Source: Medline
- NIGMS NIH HHS [P50 GM085273] Funding Source: Medline
- FDA HHS [P20 BM0066283] Funding Source: Medline
Release of inflammatory mediators by mast cells in type 1 immediate-hypersensitivity allergic reactions relies on antigen-dependent increases in cytosolic calcium. Here, we used a series of electron microscopy images to build a 3D reconstruction representing a slice through a rat tumor mast cell, which then served as a basis for stochastic modeling of inositol-trisphosphate-mediated calcium responses. The stochastic approach was verified by reaction-diffusion modeling within the same geometry. Local proximity of the endoplasmic reticulum to either the plasma membrane or mitochondria is predicted to differentially impact local inositol trisphosphate receptor transport. The explicit consideration of organelle spatial relationships represents an important step toward building a comprehensive, realistic model of cellular calcium dynamics.
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