期刊
BIOSENSORS-BASEL
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/bios10030016
关键词
testosterone; molecular imprinting; electronically conductive polymer; electrochemical sensing; urine
资金
- Ministry of Science and Technology of ROC [MOST 104-2220-E-390-001, MOST 105-2221-E-390-026, MOST 105-2918-I-390-001]
Molecularly imprinted polymers (MIPs) can often bind target molecules with high selectivity and specificity. When used as MIPs, conductive polymers may have unique binding capabilities; they often contain aromatic rings and functional groups, which can undergo pi-pi and hydrogen bonding interactions with similarly structured target (or template) molecules. In this work, an electrochemical method was used to optimize the synthetic self-assembly of poly(aniline-co-metanilic acid) and testosterone, forming testosterone-imprinted electronically conductive polymers (TIECPs) on sensing electrodes. The linear sensing range for testosterone was from 0.1 to 100 pg/mL, and the limit of detection was as low as similar to pM. Random urine samples were collected and diluted 1000-fold to measure testosterone concentration using the above TIECP sensors; results were compared with a commercial ARCHITECT ci 8200 system. The testosterone concentrations in the tested samples were in the range of 0.33 +/- 0.09 to 9.13 +/- 1.33 ng/mL. The mean accuracy of the TIECP-coated sensors was 90.3 +/- 7.0%.
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