期刊
BIOPHYSICAL JOURNAL
卷 95, 期 10, 页码 4529-4539出版社
CELL PRESS
DOI: 10.1529/biophysj.108.134783
关键词
-
类别
资金
- National Science Foundation [CHE-0613331]
- Penn Materials Research Science and Engineering Center [DMR-0520020]
We present the first numerical simulation of actin-driven propulsion by elastic. laments. Specifically, we use a Brownian dynamics formulation of the dendritic nucleation model of actin-driven propulsion. We show that the model leads to a self-assembled network that exerts forces on a disk and pushes it with an average speed. This simulation approach is the first to observe a speed that varies nonmonotonically with the concentration of branching proteins (Arp2/3), capping protein, and depolymerization rate, in accord with experimental observations. Our results suggest a new interpretation of the origin of motility. When we estimate the speed that this mechanism would produce in a system with realistic rate constants and concentrations as well as fluid flow, we obtain a value that is within an order-of-magnitude of the polymerization speed deduced from experiments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据