期刊
BIOENGINEERING-BASEL
卷 7, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/bioengineering7010025
关键词
the mitral valve; the tricuspid valve; collagen fiber architecture; glycosaminoglycan; uniaxial mechanical testing; in-vitro flow loops; polarized spatial frequency domain imaging
资金
- American Heart Association Scientist Development Grant (SDG) Award [16SDG27760143]
- Presbyterian Health Foundation Team Science Grants [C5122401]
- School of Aerospace and Mechanical Engineering (AME)
- IBEST-OUHSC Seed Funding for Interdisciplinary Research
- Research Council at the University of Oklahoma
The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary muscles. Specifically, the chordae tendineae are critical to distributing forces during systolic closure from the leaflets to the papillary muscles, preventing leaflet prolapse and consequent regurgitation. Current therapies for chordae failure have issues of disease recurrence or suboptimal treatment outcomes. To improve those therapies, researchers have sought to better understand the mechanics and microstructure of the chordae tendineae of the AHVs. The intricate structures of the chordae tendineae have become of increasing interest in recent literature, and there are several key findings that have not been comprehensively summarized in one review. Therefore, in this review paper, we will provide a summary of the current state of biomechanical and microstructural characterizations of the chordae tendineae, and also discuss perspectives for future studies that will aid in a better understanding of the tissue mechanics-microstructure linking of the AHVs' chordae tendineae, and thereby improve the therapeutics for heart valve diseases caused by chordae failures.
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