期刊
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
卷 14, 期 1, 页码 1386-1401出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/16583655.2020.1812269
关键词
Luteolin; self-nanoemulsifying system; solubility; permeation; DPPH; anti-inflammatory
资金
- Deanship of Scientific Research at Prince Sattam bin Abdulaziz University
The purpose of this study was to develop a self-nanoemulsifying drug delivery system (SNEDDS) for the improvement of solubility and bioavailability of luteolin in order to enhance its therapeutic benefits. Formulations were prepared by spontaneous emulsification method which involved low energy mixing of appropriate amounts ofcastor oil, kolliphor & polyethylene glycol 200. The developed formulae were optimized and characterized for self-nanoemulsifying capacity, thermodynamic stability, size behaviour and solubility. The globule size of the optimized formula F1-A1:1 was 112 +/- 15 nm, with narrow PDI (0.31 +/- 0.09) and good zeta potential (-16.2 +/- 3.2 mV). The optimized formula exhibited approximately 83, 17 and 3-fold enhancement in the solubility in vitro release and ex vivo permeation respectively. The luteolin SNEDD exhibited better antioxidant activity (DPPH scavenging activity) than ascorbic acid. Per cent inhibition in rat paw oedema by the SNEDDS formulation was statistically significant when compared with luteolin suspension at equivalent dose (P < 0.05).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据