期刊
BIOPHYSICAL CHEMISTRY
卷 182, 期 -, 页码 23-29出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bpc.2013.07.010
关键词
A beta toxicity; Supported lipid bilayers; In liquid AFM; Force spectroscopy
资金
- MERIT 'Basi molecolari nelle sindromi degenerative correlate con l'invecchiamento'
- FIRB RBFR12SIPT MIND: 'Indagine multidisciplinare per lo sviluppo di farmaci neuro-protettori'
Beta-amyloid (1-40) is one of the two most abundant species of amyloid-beta peptides present as fibrils in the extracellular senile plaques in the brain of Alzheimer's patients. Recently, the molecular aggregates constituting the early stage of fibril formation, i.e., oligomers and protofibrils, have been investigated as the main responsible for amyloid-beta cytotoxic effect. The molecular mechanism leading to neurodegeneration is still under debate, and it is common opinion that it may reside in the interaction between amyloid species and the neural membrane. In this investigation Atomic Force Microscopy and spectroscopy have been used to understand how structural (and mechanical) properties of POPC/POPS lipid bilayers, simulating the phospholipid composition and negative net charge of neuritic cell membranes, are influenced by the interaction with A beta(1-40), in different stages of the peptide aggregation. Substantial differences in the damage caused to the lipid bilayers have been observed, confirming the toxic effect exerted especially by A beta(1-40) prefibrillar oligomers. (c) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据