期刊
BIOPHYSICAL CHEMISTRY
卷 153, 期 1, 页码 61-69出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bpc.2010.10.005
关键词
Aminostyryl quinolinum dye; Fluorescence correlation Spectroscopy; Solvatochromism
资金
- Texas Emerging Technology
- DOD [BC093521]
The stytyl group of dyes has been used in cellular studies for over 20 years because of their solvatochromic and/or electrochromic properties. Here we report characterization of solubility and solvatochromic properties of a near infra-red styryl dye, styryl 11 or LDS 798. We have extended our studies to small unilamellar vesicles and lipid based nanoparticles and found that solvatochromic properties of this dye used in tandem with fluorescence correlation spectroscopy can be used to efficiently determine the diffusion coefficient and hence the size of the submicron lipid based particles. This technique has the potential to provide essential information about liposomal and vesicular structures and their movement in vitro and in situ. Published by Elsevier B.V.
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