相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。BDDCS Applied to Over 900 Drugs
Leslie Z. Benet et al.
AAPS JOURNAL (2011)
Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science
Malcolm Rowland et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011 (2011)
Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling
Hannah M. Jones et al.
CLINICAL PHARMACOKINETICS (2011)
Predicting Clearance in Humans from In Vitro Data
R. Scott Obach
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)
Have physiologically-based pharmacokinetic models delivered?
Andrea N. Edginton et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2011)
PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the PhRMA Dataset, and Comparison with Literature Datasets
Patrick Poulin et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 2: Comparative Assessment of Prediction Methods of Human Volume of Distribution
Rhys Do Jones et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Assessment of in silico models for fraction of unbound drug in human liver microsomes
Hua Gao et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2010)
Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development
Masato Chiba et al.
AAPS JOURNAL (2009)
Modelling and PBPK Simulation in Drug Discovery
Hannah M. Jones et al.
AAPS JOURNAL (2009)
The Simcyp® Population-based ADME Simulator
Masoud Jamei et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding
C. Emoto et al.
XENOBIOTICA (2009)
Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays
J. Brian Houston et al.
CURRENT DRUG METABOLISM (2008)
Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use of in silico physiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man
G. Allan et al.
XENOBIOTICA (2008)
Prediction of intestinal first-pass drug metabolism
Jiansong Yang et al.
CURRENT DRUG METABOLISM (2007)
Challenges and opportunities with modelling and simulation in drug discovery and drug development
T. Lave et al.
XENOBIOTICA (2007)
Prediction of human pharmacokinetics using physiologically based modeling: A retrospective analysis of 26 clinically tested drugs
Stefan S. De Buck et al.
DRUG METABOLISM AND DISPOSITION (2007)
In vitro-in vivo correlation of hepatobiliary drug clearance in humans
G. Ghibellini et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
The impact of in vitro binding on in vitro -: In vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions
K Grime et al.
CURRENT DRUG METABOLISM (2006)
A novel strategy for physiologically based predictions of human pharmacokinetics
HM Jones et al.
CLINICAL PHARMACOKINETICS (2006)
Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability
E. M. Howgate et al.
XENOBIOTICA (2006)
A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes
RJ Riley et al.
DRUG METABOLISM AND DISPOSITION (2005)
Tissue distribution of basic drugs:: Accounting for enantiomeric, compound and regional differences amongst β-blocking drugs in rat
T Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Physiologically based pharmacokinetic modeling 1: Predicting the tissue distribution of moderate-to-strong bases
T Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Determination of volume of distribution at steady state with complete consideration of the kinetics of protein and tissue binding in linear pharmacokinetics
LM Berezhkovskiy
JOURNAL OF PHARMACEUTICAL SCIENCES (2004)
The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties
RP Austin et al.
DRUG METABOLISM AND DISPOSITION (2002)