期刊
CLINICAL & TRANSLATIONAL IMMUNOLOGY
卷 9, 期 5, 页码 -出版社
WILEY
DOI: 10.1002/cti2.1128
关键词
COVID-19; HLA-G; peripheral immune cells; SARS-CoV-2
类别
资金
- Taizhou Technology Project, Zhejiang Province [1901ky01, 1901ky04, 1901ky09]
Objectives Host immune responses are indispensable to combat the disease. We report the dynamics of peripheral immune cells, cytokines, and human leucocyte antigen-G (HLA-G) and its receptor expressions in a patient suffering from critical COVID-19 pneumonia to convalescence. Methods Clinical data of the patient were collected from medical records. The expressions of HLA-G and receptors ILT2, ILT4 and KIR2DL4 in peripheral immune cells were measured with flow cytometry. Results From critical COVID-19 to the convalescent stage, early lymphopenia was improved (median: 0.6 x 10(9) L-1 vs. 0.9 x 10(9) L-1, P = 0.009), and an obvious fluctuation in WBC and neutrophil counts was observed. Initially, low levels of CD4(+) T cells (from 120 to 528 mu L-1) and CD8(+) T cells (from 68 to 362 mu L-1) gradually increased to normal levels. Meanwhile, high IL-6 (from 251.8 to 6.32 pg mL(-1)), IL-10 (from 39.53 to 5.21 pg mL(-1)) and IFN-gamma (from 13.55 to 3.16 pg mL(-1)) levels decreased, and IL-4 (from 2.36 to 3.19 pg mL(-1)) and TNF-alpha (from 2.27 to 20.2 pg mL(-1)) levels increased quickly when the viral RNA returned negative. Moreover, the percentage of HLA-G(+) T cells, B cells and monocytes follows high-low-high pattern, while the percentage of receptors ILT2-, ILT4- and KIR2DL4-expressing cells remained relatively stable. Conclusion Our findings provide valuable information on the dynamics of early peripheral immunological responses in SARS-CoV-2 infection. CD4(+) and CD8(+) T cells, cytokines and HLA-G(+) immune cells are associated with the natural history of the critical COVID-19 patient; however, future studies are necessary.
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