期刊
出版社
WILEY
DOI: 10.1002/dad2.12035
关键词
Alzheimer's disease; blood pressure; cognitive decline; hypertension; hypotension; longitudinal; mild cognitive impairment
资金
- National Institutes of Health [U01AG024904]
- Department of Defense [W81XWH-12-2-0012]
IntroductionUnderstanding relationships among blood pressure (BP), cognition, and brain volume could inform Alzheimer's disease (AD) management. MethodsWe investigated Alzheimer's Disease Neuroimaging Initiative (ADNI) participants: 200 controls, 346 mild cognitive impairment (MCI), and 154 AD. National Alzheimer's Co-ordinating Center (NACC) participants were separately analyzed: 1098 controls, 2297 MCI, and 4845 AD. Relationships between cognition and BP were assessed in both cohorts and BP and atrophy rates in ADNI. Multivariate mixed linear-regression models were fitted with joint outcomes of BP (systolic, diastolic, and pulse pressure), cognition (Mini-Mental State Examination, Logical Memory, and Digit Symbol) and atrophy rate (whole-brain, hippocampus). ResultsADNI MCI and AD patients with greater baseline systolic BP had higher hippocampal atrophy rates ([r, P value]; 0.2, 0.005 and 0.2, 0.04, respectively). NACC AD patients with lower systolic BP had lower cognitive scores (0.1, 0.0003). DiscussionHigher late-life BP may be associated with faster decline in cognitively impaired elders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据