期刊
BIOORGANIC CHEMISTRY
卷 43, 期 -, 页码 37-43出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2011.11.005
关键词
Uracil methylation; Thymidylate synthase; Flavin; Enzyme mechanism
资金
- NIH [R01 GM065368]
- NSF [CHE 0715448]
- NSF GRFP
- Iowa CBB
Uracil methylation is essential for survival of organisms and passage of information from generation to generation with high fidelity. Two alternative uridyl methylation enzymes, flavin-dependent thymidylate synthase and folate/FAD-dependent RNA methyltransferase, have joined the long-known classical enzymes, thymidylate synthase and SAM-dependent RNA methyltransferase. These alternative enzymes differ significantly from their classical counterparts in structure, cofactor requirements and chemical mechanism. This review covers the available structural and mechanistic knowledge of the classical and alternative enzymes in biological uracil methylation, and offers a possibility of using inhibitors specifically aiming at microbial thymidylate production as antimicrobial drugs. (C) 2011 Elsevier Inc. All rights reserved.
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