期刊
BIOORGANIC CHEMISTRY
卷 39, 期 1-3, 页码 67-72出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2011.02.002
关键词
Bridgehead fragments; Conformational restriction; Melatonin receptors
资金
- Russian Foundation for Basic Research [09-03-879, 09-03-12110-ofi]
Conformationally constrained analogues of the hormone melatonin with a side chain incorporated into the bicyclic bridgehead core were synthesized based on the homology modeling and molecular docking studies performed for the MT2 melatonin receptor. The methoxy-indole derivative fused with exo-N-acetamino-substituted bicyclo[2.2.2]octane was found to possess nanomolar MT2 receptor affinity. (C) 2011 Elsevier Inc. All rights reserved.
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