期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 3, 页码 756-759出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2013.12.109
关键词
7-Chloroquinoline; Isatin; 3-Hydroxy-indole-2-one; 1H-1,2,3-Triazole; Antimalarial activity
资金
- Board of Research in Nuclear Sciences under DAE Research Award
A series of 1H-1,2,3-triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates have been synthesized and evaluated for their antimalarial activity against chloroquine-resistant W2 strain of Plasmodium falciparum. The most potent of the test compound with an optimum combination of 3-hydroxy-indole ring and a n-butyl linker displayed an IC50 value of 69 nM. (C) 2013 Elsevier Ltd. All rights reserved.
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