期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 7, 页码 1654-1656出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.02.071
关键词
Fluorescent; Nucleic acid; Aggregation-induced emission; Gel electrophoresis; Cell imaging; Dye
资金
- National Basic Research Program of China [2012CB720600, 2012CB720603]
- National Science Foundation of China [91213302, 21072115, 21272181]
- National Grand Program on Key Infectious Disease [2012ZX10003002-014]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1030]
A new kind of aggregation-induced emission compound was synthesized and used as the probe of nucleic acid. The characterization of this compound was studied. Both the RNA and DNA were detected by using this probe. And the detection scope of DNA and RNA was different. We researched the selectivity of our probe in double and single strand DNA sequences. The visualization of gel electrophoresis and the cell nucleus imaging were researched as well. Compared with the traditional nucleus dye Hoechst 33258, our probe also has the potential to be nucleus dye. And the cell toxicity was well performed by MTT assays. (C) 2014 Elsevier Ltd. All rights reserved.
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