期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 14, 页码 3073-3078出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.05.010
关键词
Carborane conjugates; Nucleosides; Reactive oxygen species (ROS); Oxidative burst; Neutrophils
资金
- European Regional Development Fund under Operational Programme Innovative Economy [POIG.01.01.02-10-107/09]
- IMB PAS
An impact of adenosine modification with electroneutral, lipophilic 1,12-dicarba-closo-dodecaborane or electronegative 7,8-dicarba-nido-undecaborane boron cluster at the 6-N, 2'-C and 2-C positions on human neutrophil oxidative burst, neutrophil adherence to fibronectin and protein kinase C activity was studied. Modification of adenosine with 1,12-dicarba-closo-dodecaborane, but not 7,8-dicarbanido-undecaborane, changes the function of adenosine from an inactive to an active state in regulating neutrophil response to PMA stimulation by reducing neutrophils' reactivity through a mechanism involving the PKC signaling pathway. Our results show that exogenously administered adenosine derivatives can be useful in regulating the oxidative burst of neutrophils in the inflammatory process. (C) 2014 Elsevier Ltd. All rights reserved.
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