期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 24, 期 13, 页码 2897-2899出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2014.04.099
关键词
Biginelli reaction; Multicomponent reaction; Solvent less; Graphite catalysis; Dihydropyrimidinones; alpha-Amylase inhibition; Antidiabetic
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi
- CSIR
- Department of Biotechnology, New Delhi
A solvent free three component condensation reaction between an aldehyde, ethyl acetoacetate and urea catalyzed by graphite, a green catalyst is described for the synthesis of dihydropyrimidin-2(1H)-ones. This protocol is scalable and the catalyst is reusable. This method is also applied for the synthesis of dihydropyrimidin-2(1H)-thiones. alpha-Amylase, a key enzyme in carbohydrate metabolism is generally targeted for management of type 2 diabetes. The therapeutic potential of the dihydropyrimidinones and dihydropyrimidinthiones to inhibit alpha-amylase activity was evaluated by in vitro assay. Of the synthesized compounds 3,4-dihydropyrimidin-2(1H)-thione (1k) demonstrated highest inhibition of a-amylase activity. (C) 2014 Elsevier Ltd. All rights reserved.
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